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Literature summary for 2.4.1.226 extracted from

  • Kalathas, D.; Theocharis, D.A.; Bounias, D.; Kyriakopoulou, D.; Papageorgakopoulou, N.; Stavropoulos, M.S.; Vynios, D.H.
    Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer (2011), Mol. Med. Rep., 4, 363-368.
    View publication on PubMed
Search for more literature for 2.4.1.226

Cloned(Commentary)

Cloned (Comment) Organism
RT-PCR expression analysis of CHSY1, CHSY3 and CSGlcA-T from macroscopically normal and pathological specimens, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus CHSY1, CHSY2 and CHSY3 possess dual, glucuronyltransferase and galactosaminyltransferase enzymatic activities, while the CSGlcA-T acts only by transferring glucuronic acid ?
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 ?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan Mus musculus
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 UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
additional information RT-PCR expression analysis of CHSY1, CHSY3 and CSGlcA-T from macroscopically normal and pathological specimens, overview. CHSY1 expression is increased by about 7fold in the adjacent normal tissue of the benign tumors compared to the tumor and healthy control tissues. In the tumor specimens, CHSY1 expression is high during the early stages. The CHSY3 gene is expressed equally and at very low levels in the macroscopically normal and tumor specimens. In benign tumors, CSGlcA-T is markedly elevated by about 40fold compared to the adjacent normal and healthy tissues, while in the cancer specimens it is decreased Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CHSY1, CHSY2 and CHSY3 possess dual, glucuronyltransferase and galactosaminyltransferase enzymatic activities, while the CSGlcA-T acts only by transferring glucuronic acid Mus musculus ?
-
 ?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
-
 Mus musculus UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
-
 ?

Synonyms

Synonyms Comment Organism
chondroitin sulfate glucuronyltransferase
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 Mus musculus
CHSY1
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 Mus musculus
CHSY2
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 Mus musculus
CHSY3
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 Mus musculus
CSGlcA-T
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 Mus musculus